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Several of them described a strong relationship between depression and mortality and some could not detect a linkage at all.
However, the selection criteria of the families, differences in the population background, or clinical and genetic heterogeneity might determine the power to detect a linkage signal.
We performed an analysis on a pedigree of 15 WES samples with a high level of missingness (median of medians of coverage 3, range [2, 9]) due to poor WES data generation, yet we were still able to detect a linkage peak and rapidly identify the causal variant despite the inability to identify the variant in many samples due to low coverage (Eggers et al. 2014).
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A more refined understanding of the various phenotypic expressions of a gene related to schizophrenia would enhance the power of studies designed to detect a genetic linkage with a major chromosomal locus and would benefit other strategies for understanding the etiology of schizophrenia.
Most strikingly, we could detect a possible linkage between conserved calcineurin signaling pathway and iron homeostasis.
This was performed in order to detect a direct linkage between HP1β induced mRNA alterations and the binding of the HP1β protein along the nucleosome.
We carried out a genome-wide linkage analysis in three isolated populations and we detected a strong linkage between VEGF serum levels and the 6p21.1 VEGF region in all samples.
We also applied the proposed method to a set of real data and detected a coincident linkage responsible for determining bone mineral density and areal bone size of wrist in humans.
Gahan et al. [ 5] studied the Heliothis virescens YHD2 resistant strain and detected a strong linkage between the resistance to Cry1Ac toxin and the disruption of a cadherin gene.
However, we detected a critical linkage disequilibrium haplotype block spanning 163 kb that comprises three members of the family (MS4A2, MS4A6A, and MS4A4) and the top four meta-GWAS-significant markers (Additional file 4).
The study was originally powered (90%) to detect a 27% increase in linkage to care in the intervention arm.
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