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Alternately, we will have over 95%% power at a two sided alpha = 0.05 to detect a hazards ratio of 1.20 or greater [ 24].
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A Hazard Change Detection Task was developed to measure how quickly drivers can detect a hazard in a static image regardless of whether they consider it hazardous or not.
The FPRP was calculated using a low prior probability of 0.0001, which is expected for a random SNP, to detect a hazard ratio of 1.3.
This sample size will provide ≥ 90% power to detect a hazard ratio of 0.7 for OS with 2-sided type I error of 0.04, and to detect a hazard ratio of 0.667 for PFS 2-sided type I error of 0.01.
This allows the identification of those participants who are indeed able to detect a hazard in a certain scenario, but still have deficits in response time, compared to more experienced drivers.
A prospective analysis demonstrated 80%to88%8% power to detect a hazard ratio of ≥1.3 for minor allele carriers.
The primary end point was progression-free survival (PFS) from random assignment for maintenance placebo versus sunitinib using a one-sided log-rank test with α =.15; 80 randomly assigned patients provided 89% power to detect a hazard ratio (HR) of 1.67.One hundred forty-four patients were enrolled; 138 patients received chemotherapy.
I call these the Big Three -- driving too fast for road conditions (including following too closely), failing to detect a hazard and distraction -- not risk-taking or aggressive driving.
We had 80% power to detect a hazard ratio of 1.57 under the tested recessive model of inheritance, given our sample size of 704 participants and a minor allele frequency of 17%.
We calculated that 139 patients with culture-confirmed typhoid fever would be needed in each treatment arm to detect a Hazard Ratio of 1.40 with two-sided alpha of 0.05 and power of 0.80 [14].
The sample size required for 90% power to detect a hazard ratio of 0.6 (protective efficacy [PE] OF 40%, PE defined as [1- hazard ratio] ×100%) assuming alpha = 0.017 to correct for three pair wise comparisons was 1000 infants (250 per arm).
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