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Details of dose adjustments were not available for most of the studies reviewed.
Full details of dose reductions for grade 1 or 2 toxicities are available from the authors.
The details of DOSE (digital organism simulation environment) had been described [ 18, 21– 23].
Details of dose modifications and reductions have been described previously (Kubota et al, 2008).
Details of dose regimens and sampling schedules are presented in Table 1.
The dosimetric data used in the original analyses were based on records in the NRRW, augmented by more details of dose timing.
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The details of dosing for a pandemic vaccine are not yet known, but it is clear that even if all the capacity was switched to pandemic flu there would still be a huge global shortfall.
Three patients were said to respond to a trial of amitriptyline but no details of dosing were given [9].
These include reversibility, susceptible populations, multiple end points, and the details of dose-response and dose-effect distributions.
Details of doses and toxicity are listed in Table 3. Delivered dose intensity, due to either poor general conditions or toxicity, was approximately two-thirds of projected dose intensity (Table 3).
Details of dosage, mean daily doses of trial drugs, and concomitant medication are in Additional file 2 [see Additional file 2].
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