‡Percent adherence to recommended course per AAP guidelines, see online appendix for details of how adherence was calculated.
Specific details of exercise adherence over the longer term will be requested within the 6 month follow up questionnaire.
For the analysis of LO activities, neutrophils and monocytes were routinely isolated from human peripheral blood of healthy adult male and female donors according to reported methods (for details of monocyte isolation via adherence, see Supplementary Materials online) or by positive and negative immunomagnetic selection, respectively (applicable for Figure 5 E and F).
Extracted data included details of study design, population characteristics, definition of adherence, method of measuring adherence, therapy details, determinant variables and point estimates for adherence.
Details of the sample, non-adherence measure and potential associates examined were extracted and tabulated by the first reviewer and verified by the second and third reviewers.
In this case, the details of the barriers to guideline adherence were to a large extent confirmed in the survey, whereas the main impression or finding; the scepticism of governmental guidelines, was not confirmed.
This trial is registered as Current Controlled Trials (ISRCTN58719694) More details of the intervention, of patient adherence to the intervention and to non-pharmacological treatment, and the analysis of effectiveness have been published in the protocol for analysis of the effectiveness of the intervention [ 21].
Based on the food frequency questionnaire, we derived a score of the alternate healthy eating index, an indicator of adherence to healthy eating behavior, described in detail elsewhere.
Adherence to and details of NSAID therapy (dose, drug, frequency) were rarely specified.
It also highlights study practices and procedures that can detract from the appropriate evaluation of human relevance of results, indicating the importance of adherence to international consensus protocols, such as those detailed by OECD.
