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Further elucidation of the details downstream of VEGF-A receptor activation could be critical in the development of a more holistic strategy for preserving the proper function of retinal neurons.
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No workshop participant asked to detail downstream impacts during the workshop, even though they went on to receive an introduction to VMEP that outlined the way these components are usually represented.
The results suggested that cyclin A2 is directly involved in the checkpoint of cell differentiation pathways and is a key regulator of this process, although the detail downstream mechanisms are not known.
Studies are planned to dissect in detail the downstream mediators of IL-3 and v-Abl posttranscriptional control of mRNAs in order to facilitate the development of "post-transcriptional" therapeutics for leukemia.
Subsequently we have shown in detail the downstream pathways of Caspase8 activation leading to cell death in neuronal and non-neuronal cells [ 2].
Collectively, these findings detail the downstream molecular mechanisms underlying AL amyloid cardiomyopathy and highlight potential targeting of autophagy and lysosomal dysfunction in patients with amyloid cardiomyopathy.
REACH provides two mechanisms to address the appropriateness of exposure scenarios: the option to make details of a downstream use known to the registrant to enable him to prepare appropriate exposure scenarios (articles 37(2) and (3)) or the option of upstream communication of inappropriate RMM in received exposure scenarios (Article 34).
Furthermore, the exact details of this downstream pathway are still not completely clear.
However, details of how downstream signaling events are initiated from these receptors remain to be elucidated.
The involvement of hEGR1 in the EGFR stimulation of bladder tumour cells adds further detail to the downstream effects of intracellular signalling from EGFR in bladder tumours.
Even if these hints will not provide detailed information about downstream mechanism (e.g. signal transduction), they could serve as an " door opener" for further research.
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CEO of Professional Science Editing for Scientists @ prosciediting.com