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This chapter presents a balanced view associated with therapeutic strategies aimed at modulating methyltransferase activity in breast cancer, detailing the complexity of this process mediated by the DNA methyltransferase family and their targeting to specific DNA positions through interaction with sequence recognition factors.
Future studies should explore whether other patient characteristics than those used would better predict the number of contacts and conversation topics; for instance characteristics better detailing the complexity of the home or medical situation of the patient may be more appropriate.
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In 2006 and 2007, two studies published in Science detailed the complexity of the breast cancer mutation spectrum and highlighted the major difficulties this diversity raises in designing therapies [ 3, 4].
Waving my book around like a wet rag, he went on to itemize his (many) complaints with Amazon in general, then began detailing the formidable complexities of Amazon's bookkeeping he'd have to deal with if he took my book.
In a subsequent e-mail, she detailed the additional complexity of the live camera work that must create the illusion of the match being broadcast on television, and the need for the chess moves to be timed and accurate because they can be seen in close up on the screens.
When descriptions of data values are too detailed, the computational complexities involved in mining useful knowledge from the database generally increases.
The case details the complexity of planning and implementing such a transition, focusing among other things on the transition arrangements required to ensure continuity of services and minimum of workforce disruption.
This paper details the complexity of modeling the three-dimensional thermofluid domain between the inner surface of the suit and under garments that includes mass as well as heat transfer, suiting geometry, human metabolism and respiration and effects of limb movements.
Additional file 1 details the complexity of the molecular formulae.
Despite the plethora of theoretical and empirical research involving spatial models, researchers have not considered in great detail the complexity of the decision task that a candidate confronts.
The look of it, the other actors, the detail, the complexity, the quality of the whole event".
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