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Further detailed studies needed to determine phosphorylation of CDK9 in the large P-TEFb complex or in complex with transcriptional activaton.
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However, detailed studies need to be carried out to confirm their properties both in vitro and in vivo condition.
Much more detailed studies need to be carried out in future work in order to unravel the nature of these complex interactions and to understand the functions of these two protein families in their normal cellular contexts.
This result suggests that granulocytes may be up-regulating the expression of innate immune response genes whereas the monocytic cells are suppressing it, but more detailed studies need to be done simultaneously on specific cell populations of the same patient.
Clearly, more detailed studies need to be performed to fully understand the interplay between oligomerization and stability, which could then be the basis for rational stability engineering.
More detailed studies need to be carried out to determine the structure of a real GRN and extend the control scheme to more general cases.
More detailed studies need to address under which conditions this second splice variant is expressed and the full-length protein is targeted to peroxisomes.
More detailed studies need to be conducted to identify the extent of biotransformation that OC might undergo in different environments, in addition to assessing the susceptibility of OC to photodegradation.
The preliminary evidences supporting functional role of reduced HDAC4 in drug resistant cancer cells are available and more detailed studies need to be performed to further understand the complex relationship between microRNAs, HDACs, EMT and CSCs – all of which play important roles in determining response to conventional therapeutics.
Since T2* values are influenced by a number of factors like field inhomogeneity, tissue oxygenation, blood flow and tissue distribution of paramagnetic substances like iron, a much more detailed study needs to be conducted to ascertain the causative factors behind this observation[32].
A more detailed study needs to be done to carefully assess the effect of these practical choices on the method's accuracy and efficacy.
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