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Detailed adherence to the exercise interventions is reported elsewhere (Courneya et al, 2013).
While laboratory manuals described the collection and storage of plasma and serum, the detailed adherence to the procedures was not monitored continuously at each site.
The interview at the end of the measurement period asked for a general impression of the use of the bottle and the notes form, not for detailed adherence information.
In order to maximize treatment fidelity, plans to collect detailed adherence data at frequent intervals have been built into the design of the iCST trial to ensure the intervention is delivered as intended.
This, together with the quantitative evaluation of all data taken over the first year, constitutes the primary outcomes of the study, while the detailed adherence data after 5 years form the secondary outcome, allowing for an informed estimate for the boundary conditions of a future 5-year quantitative study (see online supplementary material).
Strengths of the study included detailed adherence assessment using self-report and pharmacy claim measures in accordance with best-practices [ 33], collection of blood samples using routine phlebotomy, analysis of samples conducted in an independent laboratory on a reliable platform, effective quality control, and the use of well-trained local research staff.
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We provided NCF manuals detailing adherence-related beliefs and guidelines for eliciting and addressing these beliefs including a consultation flow chart.
We describe here in detail adherence interventions in our pediatric HIV comprehensive care program in a resource-limited setting.
Detailed information regarding adherence, safety and tolerability are found elsewhere [ 25].
However, because the infection status of sexual partners is generally unknown and participants' infection status is assessed only infrequently, such detailed adherence-based analysis is essentially impossible.
In the post-implementation period, PGDT was fully reported in 124 patients (61 %) (based on the adherence criteria detailed in the Methods section).
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