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Female-derived endopeptidases might degrade the plug and/or detach the plug from its close association to female tissue as an initial step in dislodgement.
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The tissue was attached until 12 weeks, and it was detached from the plug cartilage between 12 and 24 weeks postoperatively.
At 8 and 12 weeks postoperatively in particular, the intensity was about half that at day 0. Because of this low intensity the tissue could have become detached from the plug cartilage before 24 weeks postoperatively (Fig. 5c).
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Histology revealed that the plug sank until 2 weeks postoperatively, and that newly formed cartilage-like tissue covered the plug, but at 24 weeks the tissue detached.
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