Sentence examples for destructive mutation from inspiring English sources
We used Polyphen and MutationTaster classification tools to predict the functional consequences of amino acid changes or frameshift mutations and found that 359 genes had at least one potentially destructive mutation (Table S1) [23], [23].
Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact.
The jury's still out on that one, but scientists have now answered an equally important and related question: How did early RNA molecules grow longer and more complex without succumbing to destructive mutations?
Because destructive mutations are more common than mutations that generate or improve sophisticated biological mechanisms, mutation-driven evolution of cancer is feasible over short periods of time.
This analysis clearly showed that there was no correlation between genotype severity (more deleterious mutations vs less destructive mutations) and clinical phenotype.
More than 20% of the population was responsive to re-induction and showed strong VSG121 expression, pointing against destructive mutations in the inducible expression system.
Of the potentially destructive somatic mutations, 309 were located in positions highly conserved in 44 different species, including opossum (Monodelphis domestica), chicken (Gallus gallus) and lamprey (Petromyzon marinus).
Then, small-genome organisms survive the destructive effect of mutations on their fitness better than large-genome ones, due to lower per genome mutation rates.
Damage to genetic material would fuel increased genetic mutation, cancer and have other destructive consequences.
Ultraselfish genes, along with other parasites and harmful mutations, are representatives of the destructive force of nature.
So far, important insights into the mechanisms of RA-related destruction of cartilage have already been obtained from several animal models of arthritis, including destructive arthritis induced by various antigens, transgenic and mutation models and immunodeficient mice [ 12- 16].
