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Were it nor for cortisone and ACTH, Laurence wouldnow be either bedfast & dying or dead, for until the advent of hormone therapy, periarteritis nodosa, a destructive inflammation of the arteries, was almost always briskly fatal.
Indirect evidence of a link between mediator level and subsequent tissue damage should consist of their therapeutic removal to a threshold value at which destructive inflammation is abated.
Maintaining or restoring a state of immune homeostasis is particularly challenging at barrier sites where constant exposure to immunogenic environmental agents may induce destructive inflammation.
route can act as "smart adjuvants" for inducing protective immunity at distant mucosal surfaces while avoiding destructive inflammation.
αB crystallin has been reported to play a significant role in protecting retinal tissues during the destructive inflammation that occurs during bacterial endophthalmitis [32].
Importantly, the increased migration triggered via FasL resulted in increased inflammation and tissue damage at the injury site, indicating that FasL triggered migration is a new mechanism by which FasL can trigger destructive inflammation.
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The tissue-destructive inflammation affects all joint structures, leading eventually to total joint destruction.
In an appropriate immune response, efficient pathogen elimination and the removal of antigenic material are achieved through transient non-destructive inflammation.
We did not observe any clinical signs of inflammation from the articular cartilage, which indicated that these anti-CII specific antibodies were not arthritogenic but rather were a result of the cartilage-destructive inflammation in the trachea.
Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, causative agents of destructive chronic inflammation in the periodontium, can accelerate atheroma deposition in animal models.
It occurs as a result of chronic destructive granulomatous inflammation of the renal parenchyma as a consequence of chronic infection [ 1].
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