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It is an invasive and destructive infection that complicates the skin, subcutaneous tissue, deep fascia, and, to some extent, sparing of muscle.
Necrotizing fasciitis, more commonly known as the "flesh-eating disease," is an aggressive and highly destructive infection of fascia and muscle with a high morbidity and mortality.
By compromising her local defenses, this bacterium could proliferate rapidly, causing the destructive infection that lead to septic shock.
The clinical presentation of mediastinitis caused by the S. aureus has been observed to be a severely destructive infection for the immune system with strong signs of systemic inflammation in many of the patients.
Actinomycetoma is a slowly progressive, destructive infection of the cutaneous and subcutaneous tissues, fascia, and bones, caused by fungi (eumycetoma) or by aerobic actinomycete bacteria (actinomycetoma or actinomycotic mycetoma) and mainly prevalent in tropical countries [ 1].
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GNB, including S. algae, are involved, and an ischemic mechanism may be crucial in the development of these destructive infections.
Anthracnose and spring leaf spot, caused by the fungal pathogens Colletotrichum trifolii and Phoma medicaginis, respectively, are the most destructive infections of alfalfa worldwide.
The Epo omptin is a close homolog of Pla, exhibiting 77% sequence identity, and it is encoded on a plasmid of the plant pathogen Erwinia pyrifoliae that causes tissue-destructive infection in pear trees [ 32].
As such, destructive osteoarticular infection of the shoulder, posterior to shoulder arthroscopy procedures, is highly exceptional and challenging.
This option is gaining in evidence, and when failing, does not impede proceeding to the current accepted standard of care in destructive joint infections.
This latter is also still poorly defined and extrapolated from the highly documented and referenced experience with destructive articular infections of the hip and knee [9, 18, 20, 21, 22].
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