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"The timelines associated with this destruction phase would be ambitious under the most peaceful and benign of circumstances," he added.
Three main phases have been identified in the process of muscle regeneration; a destruction phase with the initial inflammatory response, a regeneration phase with activation and proliferation of satellite cells and a remodeling phase with maturation of the regenerated myofibers.
In general, the healing process of muscle injury consists of 3 phases: the destruction phase, the repair phase, and the remodeling phase [ 9].
The disease transitions from an initial inflammatory insult through an inflammation-driven tissue destruction phase to an osteoproliferative phase which in the worst cases results in joint fusion.
This discrepancy could be attributed to temporal segregation of the actions of Fbxl3 and Hausp, perhaps one of them is more important during the phase of Cry1/2 accumulation and the other critical during the destruction phase.
Based on the time course change in muscle function, the destruction phase, the regeneration phase, and the remodeling phase are days 0 2, days 2 5, and days 5 7 after LC, respectively.
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"This is a process of creative destruction, and the destructive phase is not yet over," said Gerald Curtis, a professor of Japanese politics at Columbia University.
These complex processes (often unknown) result in either tumor destruction (elimination phase), equilibrium phase or tumor growth (escape phase) by sculpting immunogenic cancer cells.
Because autoantibodies are passively transferred, this model focuses on immune recruitment and joint destruction (effector phase), rather than the breaking of immune tolerance (priming phase).
A coding variant in RANK, rs8092336, was significantly associated with joint destruction in phase-1 and phase-2, but did not remain significant after correction for 20 tests.
After this "creative destruction", a new phase of rapid expansion sets in.
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