Sentence examples for destruction of matrix from inspiring English sources

One of the primary causes of cartilage degradation lies in the destruction of matrix induced by elevated levels of a number of proteolytic enzymes.

MMP-3 (stromelysin 1) is known to be elevated in both OA and RA, and it promotes the destruction of matrix components of the joints [ 21].

Through the invasion-metastasis cascade, cancer cells can breach to the basement membrane to intravasate and ultimately colonize distant sites, requiring reversible changes in cell-cell and cell-extracellular-matrix (ECM) adherence, destruction of matrix and stromal proteins, and motility [ 16, 17].

On the biochemical level, OA is characterized by uncontrolled production of matrix-degrading enzymes, including aggrecanases (a disintegrin and metalloprotease with trombospondine motifs (ADAMTSs)) and matrix metalloproteinases (MMPs), which result in the destruction of cartilage matrix [ 1].

In the plaque structure, various synthesis, decomposition and secretion processes occur, e.g. inflammatory cells change the structure by secreting cytokines and proteolytic enzymes into the extracellular matrix, resulting in both decreased synthesis and enhanced destruction of extracellular matrix.

Chondrocytes can produce several catabolic cytokines such as IL-1 and TNF-α, which in turn induce the production of proteinases including matrix metalloproteinases (MMPs) and disintegrin-like and metalloproteinase with thrombospondin, that lead to the destruction of the matrix network [ 3, 4].

The failure mode of the composite was supposed to be the deformation and destruction of POM matrix around the interfacial layer under load.

The increase of OFR from 0.6 to 4.8 m3/(h kg) leads to insignificant decrease of sulphur removal and conversion degrees, since OFR rise intensifies gasification and thermal destruction of organic matrix, that causes the reduction of the number of the reactive parts of COM.

Osteoarthritis (OA) is characterized by the destruction of extracellular matrix and the loss of chondrocyte function [1].

However, since MMP-9 can create a microenvironment more favorable to invasion and metastasis through activation of growth factors, specifically TGF-β, and destruction of extracellular matrix [33], the combined biological outcome of the differing effects of TGF-β on each compartment is likely to be a further enhancement of malignant behavior (Fig. 7).

It indicates a progressive destruction of extracellular matrix.