Sentence examples for destruction both in from inspiring English sources

The findings of this study are consistent with the growing evidence that TWEAK is a mediator of the joint destruction both in animal models of RA [ 10, 11] and in human RA [ 12].

Oncostatin M is a pro-inflammatory cytokine previously shown to promote marked cartilage destruction both in vitro and in vivo when in combination with IL-1 or tumour necrosis factor alpha.

It is also an area that has known considerable destruction, both in the Fire of London in 1666 and during the Blitz of World War II.

Transmission electron microscopy revealed morphological alterations in PSPOS metacyclics such as DNA condensation, cytoplasm degradation and mitochondrion and kinetoplast destruction, both in in vitro cultures and in sand fly guts.

Estradiol treatment can ameliorate autoimmune arthritis and joint destruction both in humans and in mice [ 16- 18], and we previously showed that treatment with estradiol decreases both the systemic and local bone loss in autoimmune arthritis in mice [ 19, 20].

New insights that precede this section of the manuscript: It is clear from earlier work from our and other labs that R2 and B are essential for APC function in ßcat destruction in both cultured cells and in vivo in Drosophila.

The generation of newborn neurons is translated into maintaining the dentate gyrus integrity, in contrast to the degeneration and destruction observed both in CA1 and CA3 layers of the hippocampus, regions that do not benefit from any neuronal replacement.

In addition, recent evidence indicates that osteoclasts may participate in joint destruction in both animal models of RA and human disease [ 6, 7].

PCI-32765 treatment resulted in potent inhibition of joint synovitis, cartilage, and bone destruction in both CIA and collagen antibody-induced arthritis (CAIA) models, and inhibited inflammation and vasculitis in Arthus and passive cutaneous anaphylactic (PCA) assays.

The Annexin V positive labeling in SGNs and cochlear HCs revealed that ouabain-induced destruction in both SGNs and cochlear HCs were specifically related to or characterized by apoptosis.

On the other hand, R601a has the highest thermal efficiency and lowest total exergy destruction in both optimum cases.