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Stage of joint destruction, assessed on either radiographs or low-field MRI (0.2T), does not preclude a symptoms relief following a clinically relevant weight loss in elderly obese female patients with knee osteoarthritis.
Bone erosion was evident on day 4 after DTH-arthritis induction and afterwards, and cartilage destruction (assessed by loss of Safranin O staining of articular cartilage) was evident on day 2 after DTH-arthritis induction and afterwards.
The dramatic effect of apoptotic cell injection on the course of SCW-induced arthritis development could also be observed at the level of joint swelling and bone destruction assessed by autoradiography or using a plethysmometer during the chronic phase of arthritis compare with SCW injection alone.
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Similarly the baseline cumulative SUVmax was related to the subsequent joint destruction as assessed by X-rays (Suto et al., 2016; Yonemoto et al., 2016).
While HMGB1 serum levels significantly correlated with IL-6 (on day 7: r = 0.4896, p = 0.0152), this was not the case for brain tissue destruction as assessed by CT morphometry (data not shown).
In addition, the relative contribution of the various organisms composing the holobiont in superoxide production or destruction was assessed using cultured algae, bleached versus non-bleached corals, and metabolic inhibitors.
Periodontal destruction was assessed by measuring the alveolar bone loss.
Radiographic joint destruction was assessed using the Larsen score [27].
Associations between biochemical markers, BMD, and joint destruction were assessed by Spearman's rank correlation test.
Subsequently, cartilage destruction was assessed by safranin O staining, a method to detect proteoglycan depletion.
Inflammation and joint destruction were assessed histologically 8 days after the onset of arthritis.
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