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A ticket of two women would appear as a refreshing broom to sweep aside the discredited politics of demonization, destruction and dysfunction that most Americans detest.
The inflammation is thought to result in SG tissue destruction and dysfunction in pSS.
Rheumatoid arthritis (RA) and other inflammatory arthritis diseases are systemic inflammatory diseases of unknown aetiology, which untreated may lead to joint destruction and dysfunction, to disability and to a decreased life expectancy.
The destruction and dysfunction of pancreatic insulin-producing β-cells are hallmarks of diabetes, but the molecular links between the stresses that cause β-cell death and pathways that control β-cell function and differentiation are unclear.
Both type 1 and type 2 diabetes mellitus (DM) involve destruction and dysfunction of pancreatic islets/ β cells, and their main and long-term complication is diabetic nephropathy (DN) which has evolved as a leading cause of end-stage renal disease (ESRD).
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IFN-γ is critical for LG destruction and secretory dysfunction in the CD25−/− model of SS.
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease which can lead to destruction and physical dysfunction of joints resulting in a significant increase in morbidity and mortality.
These ROS can lead to cellular organelle injury, protein misfolding, DNA destruction, and neuronal synaptic dysfunction [ 48, 132, 136– 136].
Surfactant dysfunction, destruction and inactivation have also been demonstrated in children with acute respiratory insufficiency due to bronchiolitis [ 3, 4].
Major contributors to the early development of foot deformities include talonavicular joint destruction and tibialis posterior tendon dysfunction [ 1, 3- 5].
Major contributors to the early development of foot deformities include talonavicular joint destruction and tibialis posterior tendon dysfunction, mainly due to its rupture.
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