This may reflect on one hand the additive effect of the residues forming the hydrophobic pocket such that a single substitution does not destroy interaction and on the other hand the contribution provided by HCDR3 and the other CDR loops.
Most of the 13 mutations that destroy interactions with both Nse1 and Nse4 change residues that are buried inside the Nse3 molecule (Fig. 3A).
The second phase separation from the matrix phase appeared, as PAA was imidized at elevated temperature, which destroyed the interaction between carboxyl group of PAA and hydroxyl group of TEOS-A, and a nanoscale SiO2 particle phase formed.
Changing the RGD into the chemically similar KAE amino acids destroyed these interactions.
Most of the grasslands have been lost to the erosion that follows the plows of agriculture, Mr. Proctor said, destroying the interaction of species and soil.
And they say technology isn't destroying human interaction.
Before the abrasive particles could destroy, the interaction between the atoms of the workpiece is achieved to remove material, which has ultimately increased the cutting force consistently.
We speculate that the phosphorylation of FUNDC1 Ser13 may generate steric hindrance for LC3B binding, while the LC3B R10A mutation directly destroys the interaction between Arg10 of LC3B and Ser13 or nearby Asp14 of FUNDC1 peptide, leading to the decreased binding affinity.
To achieve a high-quality cutting, we chose the cutting speed of 80 m/s, because it produces the cutting force which can quickly destroy the interaction between the workpiece atoms [16].
We have identified twelve mutations that specifically destroy the interaction with Nse1 (Table 1).
Activation of Pak does not destroy the interaction between Glu324 and Lys383, but Lys383 is twisted in the active conformation.
