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Obstetric fistula is usually a result of prolonged, obstructed labour, but socio-economic factors such as poverty, lack of education and early marriage contribute to its onset and development, says Kirya. "Some women are destined to develop an obstetric fistula early on in life," he says.
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They were "prodromal," in the medical jargon, perhaps destined to develop a full-blown psychotic episode, perhaps not.
These two schools of thought, destined to develop into an almost worldwide and controversial movement, were built on the empiricism of Hume, on the positivism of Comte, and on the philosophy of science of Mach.
Doppler analysis of the uterine artery in the first trimester is significantly different in pregnancies destined to develop FGR, with a recent prospective study identifying a correlation between the lowest uterine artery pulsatility index value and subsequent birthweight in an unselected population [ 61].
Larvae that are destined to develop into dauer larvae have an altered metabolism, compared with non-dauer larva-destined forms [ 1], and these findings are therefore consistent with the initial stages of this move to a dauer larva-type metabolism.
The AUC can be interpreted to equal the likelihood that a person destined to develop the disease or characteristic being tested for has a higher score, comparing one person who is with another who is not going to develop the given outcome (1).
An alternate explanation could be that women who are later destined to develop SSC could already have a sub-clinical form of the disease during pregnancy affecting placental development, which then results in pregnancy complications, such as IUGR and hypertension.
However here, we were not able to demonstrate an antibody response to two different citrullinated PPAD peptides in patients destined to develop RA, suggesting that this is not an early feature in ACPA ontogeny.
Early synovitis destined to develop into RA is thus characterized by a distinct and transient synovial fluid cytokine profile.
These results may indicate that these patients are earlier in their disease pathogenesis and may be destined to develop islet-specific T-cell reactivity at a later date.
Many people destined to develop type 2 diabetes spend many years in a state of pre-diabetes which has been termed "America's largest healthcare epidemic [ 7].
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