Sentence examples for destabilizing the structure of from inspiring English sources
Overall, our results are consistent with previous reports that correlate these FRS mutations to disease states by affecting aminoacylation activity as well as destabilizing the structure of FRS [ 58].
The changes at these two positions destabilized the structure of the protein.
Furthermore, substitutions of K14, by affecting early kinetics and assembly, could destabilize the structure of the final assembly or drive the assembly into a different pathway, which would lead to different morphologies for the aggregates.
We observed that longer fatty acids progressively destabilize the structure of ACP and increase micro- and millisecond motions in residues surrounding the fatty acid binding cavity.
Our in silico modeling of the effects of these three missense mutations of the wt properties of ZC4H2 protein predicted that the mutations would destabilize the structure of ZC4H2 and thus would indirectly affect its function.
An example of a natively occurring histone H2A variant with a shortened carboxy-terminal tail is H2A.Bbd, which is present in mammalian sperm and has been experimentally shown to destabilize the structure of the nucleosome.
Although this residue (Cys284) is not at the active site for hydrolytic activity of PON1, its mutation or blockage is likely to destabilize the structure of PON1 and affect its function (Harel et al. 2004).
This force is about 5 orders of magnitudes smaller than the forces required to destabilize the structure of a protein (Cecconi et al, 2005; Borgia et al, 2008), and thus, under our experimental conditions, F s should not play an important role for TTR fibrillogenesis.
Furthermore, all nonsense or mutations of deletion in Gigaxonin are likely severely destabilizing the structure, by improper folding of the β-propeller that constitutes the KELCH domain.
