Sentence examples for destabilizing the interaction of from inspiring English sources

Eco1 acetylates cohesin's Smc3 subunit to prevent the Wapl protein from destabilizing the interaction of the cohesin ring with DNA.

Strikingly, a mutation found in patients with Meier-Gorlin syndromapsaps to a highly-conserved C-terminal segment in Orc6, destabilizing the interaction of Drosophila and human Orc6 with both Orc3 alone and with the core Orc1 5 subcomplex.

Some regulators act by increasing (enhancers) or decreasing (repressors) the rates of transcription by stabilizing or destabilizing the interactions of the polymerase with the DNA or the auxiliary components, respectively.

The N-terminal region of IF1 destabilizes the interaction of the inhibitor with F1-ATPase and may assist in removing the inhibitor from its binding site when F1Fo-ATPase is making ATP.

These data indicate that the linker insertion within or near the coiled-coil region destabilizes the interaction of the V-tip protein with the needle apparatus.

To further examine the model several mutations were introduced into the N-terminus of Ets-1 that were predicted to destabilize the interaction of the putative 11ΦA-X-ΦB13 11ΦA-X-ΦB13 11ΦA-X-ΦB13

Since ATP destabilizes the AID-αRIM1/2 interaction with core AMPK, binding of the larger ATP likely indirectly destabilizes the interaction of αRIM-1 with the nucleotide-free CBS-2.

Efrapeptins destabilize the interaction of Hsp90 with client proteins and ultimately cause client protein degradation through F1F0 ATP synthase inhibition; however, efrapeptins are nonspecific and are known to inhibit other ATP synthases and the 20S proteasome among others.

If these SNPs will be experimentally confirmed, they could have the effect of destabilizing the interaction between the miRNA and the mRNA, which could consequently avoids cleavage and lead to phenotypical variations in developmental features or in the resistance to viral infection.

While stabilizing the CBM-KD interaction and inducing formation of the C-interacting helix is associated with AMPK activation, destabilizing the interaction by mutating S108 in β1-containing AMPK complexes reduces AMPK activity.

Importantly phosphorylation of H3T3 destabilizes the interaction between the N-terminal tail of H3 with UHRF1, while H3S10 phosphorylation strongly reduces the affinity of TTD-PHD for the H3K9me3 tail.