Exact(1)
These studies illustrate that substrate-induced catalytic activation of pol β provides an optimal enzyme conformation even in the presence of a strongly destabilizing point mutation.
Similar(59)
It has also been shown that, under these conditions, microsatellite repeats and longer direct repeats in mtDNA are destabilized, although point mutations are detected at wild-type levels (Sia et al. 2008).
This may primarily occur because generalist predators can behave in such a way that promotes a functional response that is destabilizing around the point of equilibrium [10].
The presence of other planets, however principally Saturn perturbs the Sun-Jupiter-Trojan asteroid system enough to destabilize those points, and no asteroids have been found actually at them.
This results in a fresh angle on things like "gender" or "class" — to the point of destabilizing them and giving the people trapped inside these constructs liberty, and a voice.
Because previous work done in our lab showed that mutants had an accelerated physical decline beginning around 40 days old, the increase in BDNF in acutely exercised mutants at 30 days of age may signify a critical time point when destabilizing neurologic changes begin to modify the mutant cerebellum.
By linearizing about the fixed point and calculating the eigenvalues of the Jacobian, we can find regimes where the fixed point destabilizes via a Hopf bifurcation leading to the formation of a limit cycle.
On a smaller scale, noise may destabilize the fixed point of an excitable single neuron, causing oscillations whose period is linked to the time taken for an escape trajectory to return to the fixed point, a phenomenon called coherence resonance [40].
Finally, we summarize our conclusions in Section 6. Remark Earlier study in [22] examines a two-dimensional map with fast-slow structure in which a fixed point destabilizes into an invariant circle.
Gold for Private Trade A proposal from Robert B. Zoellick, the World Bank president, to use gold as a global monetary reference point could prove destabilizing.
While officials made it clear that the sites would not be closed, critics charged that the reductions would have the same effect, by destabilizing the centers to the point that they would be forced to shut down.
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