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The molecular organization of clathrin in the coat in particular, the position of the specific Hsc70 attachment site at the base of a constricted funnel of criss-crossing ankles has evolved to allow the tight attachment step in Hsc70 binding to capture a destabilizing fluctuation in clathrin conformation, so that build-up of strain at multiple vertices ultimately leads to dissociation.
Similar(58)
The matured form of a given protein remains in a dubious equilibrium, often misfolding to various degrees during its lifespan, as a result of stochastic fluctuations, presence of destabilizing mutations, stress conditions, or unique metabolic challenges, such as cancer or aging.
"It is upsetting and destabilizing.
Napster was enormously destabilizing.
The disease was very destabilizing.
"This was very destabilizing.
It's very destabilizing.
It was an immensely destabilizing landscape.
The search for stability was inherently destabilizing.
AIDS is already destabilizing Africa.
It can be literally destabilizing.
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