Sentence examples for destabilizing drug from inspiring English sources
Here the authors demonstrated that directional migration of mouse and human embryonic fibroblast-like cells were inhibited by the addition of the microtubule destabilizing drug colcemid.
In the course of further examining how mTORC1 signaling is regulated during mitosis, we observed that stalling cells in mitosis through use of the microtubule destabilizing drug nocodazole caused a shift in the mobility of raptor on SDS-PAGE, and this was reversed by in vitro phosphatase treatment of the immunoprecipitates (Figure 1a).
DOI: http://dx.doi.org/10.7554/eLife.01498.018 To determine whether PTRN-1 promotes neurite MT stabilization, we examined the interaction between ptrn-1 and the MT destabilizing drug colchicine.
As a consequence, cells that do not form pericentric heterochromatin are sensitive to the microtubule destabilizing drug thiabendazole (TBZ), as observed in ago1Δ cells (Fig 5A).
For mitotic arrest, cells were treated with 350 nM of the highly reversible microtubule destabilizing drug, TN-16 (WAKO; Kitagawa et al, 1995; Perpelescu et al, 2009), for 2 to 6 h in the growth medium.
Cooling can match or exceed the efficacy of rescue by the microtubule destabilizing drug vinblastine, which has been proposed as a therapeutic approach for AD-HSP (Orso et al., 2005).
Various components of one of these checkpoints, the mitotic spindle checkpoint, have been identified in the budding yeast Saccharomyces cerevisiae by studying the effects of microtubule destabilizing drugs.
This characteristic makes the tumor microvasculature more sensitive to destabilizing drugs compared to normal host microvasculature.
The egg yolk phosphatidylcholine/dihexadecyl phosphate/cholesterol liposomal bilayer curcumin stabilized the system proportionally to its content, while the egg yolk phosphatidylcholine/dihexadecyl phosphate system destabilized upon drug loading.
With an eye on military brass in his Cabinet and advisers in the White House, Trump appears to value military-minded solutions to problems such as destabilizing Mexico's drug war, which has claimed at least 100,000 lives since 2006.
We incubated GFP-sep4 cells with the F-actin-depolymerising drug Latrunculin A (LatA) [12], [39], [40], the microtubule-destabilizing drug benomyl (BNM) [35], [40], or their solvent dimethyl sulfoxide (DMSO).
