Sentence examples for destabilizing design from inspiring English sources

The principle of this design check requires the comparison of the stabilizing design effects of actions with the destabilizing design effects.

But Literal Hitler was an inside joke, destabilizing by design; as with any subcultural code, from camp to hip-hop, it was crafted to confuse outsiders.

Important considerations for designing metal-binding sites are that packing interactions in the binding site should be carefully considered to avoid costly reorganization energies and binding to the unfolded stable should be destabilized (negative design).

The strategy involved destabilizing a de novo designed three helix-bundle protein by substituting the residues present in its hydrophobic core with histidine and small amino acids.

Fast-GCaMPs were designed by destabilizing the association of the hydrophobic pocket of calcium-bound calmodulin with the RS20 binding domain, an intramolecular interaction that protects the green fluorescent protein chromophore.

In doing so, the use of design methods can lead to destabilizing the habitual action of participating actors, helping them to break free of existing institutions and contribute to service innovation.

The fast interconversion between possible conformers on the NMR time scale led us to construct analogs of cisplatin with bulky ligands designed to reduce the dynamic motion by destabilizing the transition state for Pt-G rotation.

However, our design rules also include avoiding polyadenylation signals and known RNA destabilizing motifs.

Modified primer design which destabilizes primer pairs has been proposed [ 13] to simplify the procedure.

In the short run, rapid growth cannot substitute for the careful design of transitional political and military frameworks and may even prove destabilizing.

Future work should focus on designing tactile pavement that does provided directional clues, but is less destabilizing.