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SCide and Scpred, which predict stability centers, as well as SRide, which predicts stabilizing residues, predict only destabilizing effects, while all the others evaluate both stabilizing and destabilizing changes.
Both viewed foreigners with ambivalence, establishing close personal relationships and drawing upon their expertise while enforcing restrictions on their activities to avert destabilizing changes to existing cultural and political systems.
By contrast, these could also primarily be amino acid stabilizing rather than destabilizing changes, and a ω > 1 may not always be indicative of adaptive evolution.
Homeostatic plasticity is important for maintaining the stability of neuronal network activity in the face of potentially destabilizing changes in the strengths of individual synapses.
One hypothesis to explain such relationships states that destabilizing changes in one position can be evolutionarily fixed if they are 'accommodated' or 'compensated' by a modification nearby.
A more specific hypothesis (Bloom et al. 2007) attributes changes in ER to changes in the stability of the protein's folded state: Stabilizing changes to the sequence lead to greater tolerance of subsequent destabilizing changes, and hence increase ER, and destabilizing changes have the opposite effect.
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Like many industries today, the legal profession is in the midst of a period of destabilizing change.
DeVito/Verdi's campaign for TelecomClick.com, which started late last month, is based on the continuing, sometimes destabilizing change in the telecommunications industry.
The news was a welcome shock to a world on the precipice of destabilizing change.
Therefore, we used TreeSAAP [ 47], which evaluates destabilizing radical changes at each site, and an empirical threshold of change in three properties was applied as evidence that a site is under positive (or negative) selection.
The evaluation of destabilizing radical changes that may occur in specific regions of proteins should complement the information obtained from positive selection analyses at the gene level.
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