Sentence examples for destabilizes the structure from inspiring English sources

The p.L152P substitution causes interatomic interference that destabilizes the structure predominantly affecting the ATP binding site and hence PRS-I activity [ 22].

This score should be devised so that the fixation probability is low if the proposed mutation destabilizes the structure or complicates the folding process.

The mutation G540E in Alsin is similar to the H425Y and R650C in Nek8 in that it lies between strands C and D and positions itself within the conserved motif between the R650C and H425Y mutation (G[R650C]L[G540E][H425Y]). Structural analysis by Soares et. al. (2009) [ 53] predicts that this mutation destabilizes the structure resulting in the observed protein delocalization and cytotoxicity.

Through the action of aromatic ring hydroxylation, oxygen is incorporated into the ring structure that further destabilizes the structure and promotes ring cleavage in the ensuing enzymatic step.

We speculate that mutation of a self-contacting residue in the buried or partially buried region of a protein will destabilize the structure.

From UV melting studies we showed a position dependent effect of UNA modifications such that quadruplexes with UNA modified loops are further stabilized whereas UNA modifications in stem of the G-quadruplex significantly destabilize the structure.

The presence of both, negatively charged gold nanoparticles (NPs) and gold cations was crucial for the activation of 2,4-dichlorobenzaldehyde via the interaction with chlorine substituent atoms and aldehyde oxygen atoms as well as breaking of the "pseudo hydrogen bond" between aldehyde hydrogen atom and chlorine substituent, which destabilized the structure making it more active.

Because protein structures are the result of their amino acid sequences, some changes can dramatically change the properties of a protein by destabilizing the structure or changing the surface of the protein in a way that changes its interaction with other proteins and molecules.

The changes at these two positions destabilized the structure of the protein.

Contacts involving many beta-branched hydrophobic residues in the crowded protein core may generate strain in helices, destabilizing the structure.

Furthermore, substitutions of K14, by affecting early kinetics and assembly, could destabilize the structure of the final assembly or drive the assembly into a different pathway, which would lead to different morphologies for the aggregates.