Sentence examples for destabilized structure from inspiring English sources

We also used the R163STOP protein in both these amorphous aggregation assays to assess its relative chaperone ability compared to the wild-type protein, but due to its destabilized structure only a limited number of assays could be performed.

UV melting experiments with RNAs have revealed a variety of stabilizing and destabilizing structures.

Nuclear dsRNA-binding proteins are known to destabilize structured pre-mRNA (Danin-Kreiselman et al, 2003; Kadener et al, 2009).

In a previous study of deleterious mutations in structured proteins, energy calculations on 3-D structures showed that the deleterious mutations were those that destabilized the structure [ 17].

It was suggested that conversion of natural savannah vegetation to cultivated crops and tillage operations destabilized soil structure in the cultivated plots mainly by an increase of the swelling forces, which, in turn, reduced the Ks values.

The changes at these two positions destabilized the structure of the protein.

In a KCl solution that induces the hybrid fold, the T=T-containing ODNs showed Tm values (Δ Tm ∼ −4 °C) slightly lower than that of the native sequence, indicating that the presence of T=T only slightly destabilized the structure.

This result surprised us as all other mutations of Ala to Pro in various β-sheets and α-helices substantially destabilized these structures.

Analysis of the three-dimensional structure showed that substitution of Phe 151 with Leu produces a hydrophobic cavity in the GSTP1 core, thereby destabilizing its structure.

Active translation destabilizes mRNA structure in cells.

Removing top predators from a community may seriously destabilize its structure and eventually cause local extinctions of other species, with cascading effect.