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As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP.
Extended conformations of the TM helices could be destabilized due to a free energy penalty of exposing large, hydrophobic side chains to the solvent.
When one or two disulfide bonds are broken, a protein is substantially destabilized due to an increase in entropy in the denatured state18.
It is unclear whether moderate drying predicted for northern peatlands will stimulate burning and carbon losses as has occurred in their smaller tropical counterparts where the carbon legacy has been destabilized due to severe drainage and deep peat fires.
This predicted timescale should be considered as the average time for Na+/Na2 release after the IC gates are broken, since the ensemble simulations covering the conformational space were initiated from the hDAT conformation in which the IC gates were destabilized due to PIP2-mediated N-term/IL4 interactions28.
Both [52] and [53] describe how, if most of the buildings in a distribution circuit have an energy-management system that turns up the air-conditioning or the heating when electricity prices drop below a threshold, then the distribution circuit, and indeed the entire grid, can be destabilized, due to the amplified spikes.
Similar(46)
Yet multiple indicators show that many complex and, until recently, stable ecosystems are destabilizing due to excessive combustion of fossil fuels.
Frozen methane hydrates along the U.S. continental shelf are destabilizing due to shifts in the Gulf Stream.
Frozen methane hydrates along the U.S. continental shelf are destabilizing due to shifts in the gulf stream.
Therefore, colloids may act as drug reservoirs; the drug will remain inactive as long as colloids remain intact, but as the colloids destabilize due to decreasing local concentration or other environmental changes, the free drug will be released.
The AMPTP has long complained that such delays destabilize showbiz due to heightened uncertainty over the prospect of a work stoppage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com