Sentence examples for destabilize the structure of from inspiring English sources

Furthermore, substitutions of K14, by affecting early kinetics and assembly, could destabilize the structure of the final assembly or drive the assembly into a different pathway, which would lead to different morphologies for the aggregates.

This additional repulsive energy would decrease the stability of bonds between layers and destabilize the structure of myelin.

This could explain how missense mutations in these positions would destabilize the structure of the KELCH domain.

We observed that longer fatty acids progressively destabilize the structure of ACP and increase micro- and millisecond motions in residues surrounding the fatty acid binding cavity.

An example of a natively occurring histone H2A variant with a shortened carboxy-terminal tail is H2A.Bbd, which is present in mammalian sperm and has been experimentally shown to destabilize the structure of the nucleosome.

Although this residue (Cys284) is not at the active site for hydrolytic activity of PON1, its mutation or blockage is likely to destabilize the structure of PON1 and affect its function (Harel et al. 2004).

Thus, the introduction of a negative charge at position 18 destabilizes the structure of Hha.

The changes at these two positions destabilized the structure of the protein.

Overall, our results are consistent with previous reports that correlate these FRS mutations to disease states by affecting aminoacylation activity as well as destabilizing the structure of FRS [ 58].

Furthermore, all nonsense or mutations of deletion in Gigaxonin are likely severely destabilizing the structure, by improper folding of the β-propeller that constitutes the KELCH domain.

Because protein structures are the result of their amino acid sequences, some changes can dramatically change the properties of a protein by destabilizing the structure or changing the surface of the protein in a way that changes its interaction with other proteins and molecules.