Sentence examples for destabilize the structure from inspiring English sources
We speculate that mutation of a self-contacting residue in the buried or partially buried region of a protein will destabilize the structure.
From UV melting studies we showed a position dependent effect of UNA modifications such that quadruplexes with UNA modified loops are further stabilized whereas UNA modifications in stem of the G-quadruplex significantly destabilize the structure.
Furthermore, substitutions of K14, by affecting early kinetics and assembly, could destabilize the structure of the final assembly or drive the assembly into a different pathway, which would lead to different morphologies for the aggregates.
Earth should not be mixed with the stone because it may be washed out and thus destabilize the structure.
This additional repulsive energy would decrease the stability of bonds between layers and destabilize the structure of myelin.
This could explain how missense mutations in these positions would destabilize the structure of the KELCH domain.
The effect of RDCs on the MD simulation was assessed by calculating rmsds of ring atoms of monosaccharides A, B, and C. The magnitude of rmsd fluctuations was identical to those observed in the unrestrained MD simulations indicating that the inclusion of RDCs did not destabilize the structures.
The presence of both, negatively charged gold nanoparticles (NPs) and gold cations was crucial for the activation of 2,4-dichlorobenzaldehyde via the interaction with chlorine substituent atoms and aldehyde oxygen atoms as well as breaking of the "pseudo hydrogen bond" between aldehyde hydrogen atom and chlorine substituent, which destabilized the structure making it more active.
Because protein structures are the result of their amino acid sequences, some changes can dramatically change the properties of a protein by destabilizing the structure or changing the surface of the protein in a way that changes its interaction with other proteins and molecules.
The changes at these two positions destabilized the structure of the protein.
