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Miyata, K. et al. Polyplexes from poly aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity.
This class embraces and celebrates destabilization, with all the exuberance, fear, and learning that can happen when we accept and practice being lost.
From experimental and clinical studies it is known that matrix conservation and degradation by matrix metalloproteinases (MMPs) plays a major role in plaque progression and destabilization with related onset of acute vascular events such as acute coronary syndromes or cerebrovascular accidents.
Taken together, these findings suggest the accumulation of LAPTM5 in NB cells to cause lysosomal cell death due to lysosomal destabilization with LMP.
Since lysosomal destabilization with LMP leads to the leakage of enzymes from the lysosome into the cytosol, we examined the subcellular distribution of cathepsin D (CTSD), a lysosomal enzyme [32].
Second, a gradual filament destabilization with time, implemented for instance by filament debranching, inevitably translates into a localized maximum of network depolymerization a few microns behind the leading edge.
Similar(42)
It is commonly observed that particles are destabilized by small amounts of hydrolyzing metal salts and that optimum destabilization corresponds with neutralization of the particles' charge.
(ii) Under high local dispersal, asynchronous local destabilization associated with weak interactions proves the driver behind global stability.
The phosphorylation level of glycogen synthase kinase-3-beta, a kinase important for beta-catenin protein destabilization, correlated with beta-catenin protein level.
The large thermodynamic destabilization associated with this substitution may arise, in part, from a loss in cooperativity among the multiple stabilizing interactions that are normally favored by the highly ordered structure of the wild-type protein.
Conversely, destabilization microtubules with nocodazole reduced cord length and increased blind ends (Fig. 3C, D).
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