Sentence examples for destabilization through from inspiring English sources

Although ubiquitylated H2B does not alter transcription through chromatin on its own, the increased stimulation of transcriptional elongation in the presence of FACT suggests that the ubiquitin modification either intrinsically destabilizes the nucleosome or assists destabilization through action of FACT.

We show that the near-perfect miRNA site selectively triggers miR-29b destabilization through 3′ trimming and restricts its spatial expression in the cerebellum.

Computational modeling of the experimentally identified mutations showed that these mutations reduced the binding affinity through one of the three scenarios: through SCF destabilization, through elimination of favorable SCF/c-Kit intermolecular interactions, or through allosteric changes.

This is a good example of destabilization through lithium reduction.

If DM acts to promote peptide binding groove destabilization through disruption of peptide/MHCII interactions near the P1 pocket, the effect of MHCII P1 polymorphism may also provide additional insights into the mechanism of DM-mediated exchange.

A second key finding is that the cell death mediated by the accumulation of LAPTM5 protein in NB cells is a lysosomal cell death with the typical features of lysosomal destabilization through LMP and with the impaired autophagy in a caspase-independent manner, as a molecular mechanism for spontaneous regression of NB tumors.

The costs to Egypt of such destabilization, and through it regional and even global security and stability, are almost impossible to calculate.

Efficient degradation of PGP-3ΔF508 PGP-3ΔF508he function of severequiredlegans ER-associathe degradation (ERAD) homologs, suggesting that destabilization occurs through an ERAD-type mechanism.

These results support the hypothesis that cyclic stretch-induced stress fiber reorganization occurs through destabilization of stress fiber integrity rather than through force sensing by FAK.

One concern with this approach is that proteolytic digestion of the bacterial surface proteins has the potential to cause cell lysis, either through destabilization of the membrane as a result of loss of membrane proteins or through activation of bacterial autolytic and/or proteolytic proteins.

This link depends on the transcription factor Nrf2, which represses STING expression through destabilization of STING mRNA.