Depending on the modules used, internal tagging of a two domain protein followed by in vivo proteolytic cleavage leads to destabilization of the whole protein, destabilization of one domain or separation of the domains.
Destabilization of one or the other is achieved using the right combination of degron and stabilizing sequence.
The functional validation of one of these mRNAs establishes a role for piRNA targeting in mRNA destabilization and embryonic development.
Sixteen years after the 9/11 attacks, our never-ending wars and conflicts continue under the rubric of "the war on terror" (no caps), as terror groups spread and destabilization creeps from one of our war zones to the next.
Due to stabilization of 7s electronic orbitals and destabilization of 6d ones caused by relativistic effects, Cn2+ is likely to have a [Rn]5f146d87s2 electronic configuration, using the 6d orbitals before the 7s one, unlike its homologues.
This could contribute to MDM2 destabilization as one function of MDMX is to stabilize MDM2.
If one or more subgenome-specific SNP s) were present in the allele-specific and/or the universal primers used in a SNP assay, then a putative "dominant" varietal SNP marker with a sequence alignment pattern as shown in Figure 1B might behave like a true co-dominant SNP marker due to the destabilization of primer binding to one of the homeologs.
Due to the stochastic destabilizations, the maximum growth rate, one of the essential parameters in microorganism cultivation, will undergo variations at different times in the turbidostat.
"Destabilization of Sudan is in no one's interest," and "to help Sudan is to help ourselves," the cable quotes China's ambassador as saying.
The positive equilibrium point of the model which is subject to an Allee effect can become either one of destabilization (see, for instance, [11, 13]) or of stabilization (see, for instance, [1, 5, 7, 10]).
