The coincidence of the "G1 blip" and the proliferation IC50 at a similar concentration range suggests that HSP90 inhibitor-induced destabilization of growth-factor receptors disrupts downstream mitogenic signaling and prevents cells from proceeding through the G1 restriction point, leading to growth inhibition and G1 accumulation.
Loss of the cell adhesion molecule N-Cadherin (Ting, 2005; Lee, et al., 2001; Nern, et al., 2008) reduces filopodial dynamics and causes destabilization of R7 growth cones, resulting in active growth cone 'jumping' between layers even days after targeting has been concluded in wild type.
In summary, we propose the following overall model to integrate our current observations with previous studies: In most cell lines, relatively low levels of HSP90 inhibitors induce G1 accumulation through destabilization of sensitive growth-factor receptors and subsequent loss of mitogenic signaling.
We therefore hypothesized that sepsis may lead to persistent vascular inflammation, which in turn could accelerate the growth or destabilization of atheromatous plaques.
Natural phenolic compounds can serve as potent redox cyclers that inhibit microbial growth through destabilization of cellular redox homeostasis and/or antioxidation systems.
Flocculation can occur in the intercrystal space, leading to a destabilization of the solid liquid interface and triggering the growth of crystals perpendicular to the main ice growth direction.
The growth factors deficiency and synaptic destabilization hypothesis of schizophrenia (GGF/SD) states that a functional deficiency of glial growth factors and of growth factors produced by glial cells such as neurotrophins and glutamate (termed here GGFs) leading to a weakening of the synaptic strength may be implicated as one of the important causes of schizophrenia (see Fig. 2).
Vessel destabilization and obliteration are critical processes in the pathogenesis of ROP where supplemental oxygen therapy and lack of growth factors causes vessel loss [45].
Pharmacological destabilization of microtubules converts a growth cone into a retraction bulb, and stabilization leads to the formation of growth cone-like structures [ 2] and increases axonal regeneration in vivo, after spinal cord injury (SCI) [ 3].
Growing tumors undergo an angiogenic switch, i. e. tumor cells start to produce angiogenic growth factors that cause destabilization of existing blood vessels, angiogenic sprouting and generation of new immature blood vessels [ 1].
Destabilization of query strain chromosomes was induced by growth on YPGAL+G418+NAT for 2 d at 25°, after which, strains were pinned to SC+FOA+G418+NAT (NAT concentration was increased to 150 µg/mL in SC media) at 30° and 37°.
