Sentence examples for destabilization event from inspiring English sources

In particular, there is data to suggest existence of such an early genomic destabilization event for colon cancer [ 71- 73].

In any event, destabilization at the mis-paired AGCA/GGTT (second green bracket) would then set the stage for the impending break by which NAHR produced the duplication of the Abp genes in this region.

Stoler et al. [ 73] showed that there are 11,000 mutations per carcinoma cell for a number of different cancer types, again implying that genomic destabilization is an early event in carcinogenesis.

In this respect microtubule stabilization protects neurons from activation of cdk5 and subsequent tau hyperphosphorylation in a cell culture model of amyloid toxicity [ 48] again suggesting that microtubule destabilization is an upstream event.

"Extreme weather events, the destabilization of the Artic.

During such events, repeated destabilization of channel bed armoring and re-mobilization of sediment temporarily stored behind LWD structures can generate bedload transport across the entire snowmelt season.

Preferential occupancy by Dnmt1 within Ctcf-positive target sites supports the intriguing hypothesis of an instructive de novo methylation that may occur when PAR synthesis is antagonized and affect the association of Ctcf with its target sequences; the consequence of such events is the destabilization of the complex in Ctcf target regions.

The characteristic "common trajectory" before the branching event reflects the destabilization of the respective progenitor state as previously observed for the hematopoietic system [22].

Interestingly, taxol exposure to either the somatodendritic or axonal compartment resulted in reduced caspase-3 activation in axons, suggesting that caspase activation is a downstream event of microtubule destabilization and involves signalling from the cell soma.

Our results suggest that increased osteoblastic activity and endothelial vessel destabilization are the two major events during human HSC mobilization.

Recently protective effects of axonal taxol have been reported in neurons exposed to 3 hours glutamate, strengthening our current results and suggesting that microtubule destabilization is an early and upstream event in axon degeneration following excitotoxicity [ 41].