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(ii) Under high local dispersal, asynchronous local destabilization associated with weak interactions proves the driver behind global stability.
The large thermodynamic destabilization associated with this substitution may arise, in part, from a loss in cooperativity among the multiple stabilizing interactions that are normally favored by the highly ordered structure of the wild-type protein.
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Lysosomal destabilization is also associated with the NLRP3 activation induced by cholesterol crystals in macrophages [ 30], probably involved in the inflammation promoting atherosclerosis.
SIRT3 siRNA reversed the OA-induced HIF1 α destabilization, suggesting that OA destabilizes HIF1 α associated with SIRT3.
We have previously demonstrated that the absence of tau protein is associated with destabilization of microtubules and impaired neurite outgrowth (Dawson et al., 2001; Rapoport et al., 2002).
The results indicate that enhanced holdase activity is associated with destabilization of the dimer interface.
These IPH are associated with destabilization of the vulnerable plaques resulting in plaque erosion and plaque rupture resulting in ACS.
This process is associated with destabilization of the transcription complex and consequent termination (El Hage et al, 2008; Kawauchi et al, 2008).
Moreover, actin severing proteins like cofilin and gelsolin have been associated with destabilization of retracting filopodia and might play a role in the bending of actin.
Because NLRP3 activation by molecules derived from the hosts is commonly associated with destabilization of phagolysosomes, we also analysed the fate of phagosomes containing M. tuberculosis.
It is believed that in general the differentiation of ES cells is associated with destabilization of pluripotency-related genes and stabilization of lineage-specific genes.
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