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A novel Notch reporter with multiple destabilisation elements provides a faithful read-out of endogenous Notch activity on a cell-by-cell basis, as neural progenitors progress through the cell cycle in the chick neural tube.
The ACS gene family consist of three classes of genes, depending on the presence of destabilisation elements in the carboxy (C) termini [ 3] that are regulated by the F-box genes ETHYLENE OVER PRODUCER (ETO) [ 4].
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As Peter Wright confirmed in his book Spycatcher, Wilson was the victim of a protracted, illegal campaign of destabilisation by a rogue element in the security services.
These alien elements seem to signal the destabilisation of heteronormative society and, in their bright, colourful patterns, celebrate the far more complicated, fluid identities that have replaced it.
MicroRNAs are short, non-coding RNA molecules that inhibit the translation and promote the destabilisation of mRNAs by base-pairing with sequence elements that are typically located in the 3′ untranslated regions (3′ UTRs) of their target transcripts (reviewed in Krol et al., 2010; Fabian and Sonenberg, 2012; Yates et al., 2013).
On the other hand, environmentally induced destabilisation of the epigenome can produce epigenetic gene variants (epialleles) that activate transcription and mobilization of DNA transposable elements, which may subsequently lead to stable heritable traits of environmental adaptation, as does occur by genetic imprinting in plants [ 499].
The destabilisation of the region featured massacres, endemic corruption, terror, even cannibalism; and, in recent years, several writers have used these elements as part of a racist polemic aimed at disparaging the Africans.
Solidarity, not destabilisation.
Pakistan has suffered terrible destabilisation.
It was a sense of chaos, destabilisation.
These shifts increase the effect of destabilisation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com