Despite expenditure of vast effort on the development of cytotoxic agents, progress in recent years has been slow.
Despite huge efforts to optimize them, the force fields currently used are still not able, in a vast majority of cases, to bring an approximate, homology-based model of protein structure (whose atoms usually deviate by only 1.5 – 3 Å from their native positions) closer to its native conformation [18 22].
However, despite huge efforts to optimize them, currently-used all-atom force fields are still not able, in a vast majority of cases, even to keep a protein molecule in its native conformation in the course of molecular dynamics simulations or to bring an approximate, homology-based model of protein structure closer to its native conformation.
We can speculate about Brady's reasons for this vast effort.
Furthermore, despite the vast computational efforts needed, such simulations are crucial to verify system level simulations.
Atopic dermatitis is a complex and multifactorial disease, and despite the vast research efforts, its pathogenesis has not been entirely elucidated yet.
Overall, they appear to have had little influence on the spread of the virus, despite vast amounts of resources and effort expended.
This lack of improvement, despite vast infusions of money and the time and energy of many dedicated people, suggests that these efforts are either trying to fix the wrong problem or using the wrong methods to address the problems [ 3- 6].
Despite vast empirical variation, we can identify particular admission patterns for elective surgery.
Despite vast political differences, they instantly became friends.
