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[1] A substantial body of randomized-controlled trial evidence has demonstrated that beta-blockers reduce mortality in patients with systolic HF. [2] [5] Despite this trial evidence, and subsequent consensus clinical practice guidelines [6], many of these patients are not receiving beta-blockers [7], [8] and proven therapy has only slowly disseminated into practice.
Despite this trial's significant results, some methodological constraints such as its small sample size (N = 10) and large number of outcome measures limited the generalisability of its findings.
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Despite this, trials of tranexamic acid continue to assess the effect on blood transfusion.
Despite this, trials of treatment targeted at Bcl-2 in SCLC are in progress (Hann et al, 2008; Rudin et al, 2008; Shoemaker et al, 2008).
Power to detect significant associations with treatment dose was quite limited despite that this trial of EDI enrolled one of the largest samples reported in L/LMIC.
Despite technical difficulties, this trial strongly suggests that the psychomotor development of DS patients may be improved by treatments acting on metabolic pathways.
Despite participants in this trial being interested and motivated to change behavior, retention of participants was a significant issue.
Despite these limitations, this trial has many design strengths which reinforce the importance of the results to policy-makers and treatment service administrators.
Despite these limitations, this trial has many strengths which reinforce the importance of the results to prevent online gambling problem and maybe to influence policy-makers.
However, despite small numbers, this trial did note the occurrence of LTLS in only 21% of patients in the rasburicase group as opposed to 41% in the allopurinol group, which was a statistically significant reduction (P<0.05); thus reduction of the incidence of LTLS by rasburicase is supported by weak level 2 evidence.
[22] We suspect over-reporting of adherence in this trial: despite SAVVY's purported contraceptive effect, [11] the similar pregnancy rates in the two groups raises doubt that the gels were used as consistently as reported.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com