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'despite their importance' is correct and usable in written English.
You can use it when you need to express that something is not as important as one might think. For example, "Despite their importance, the details of the plan still need to be worked out."
Exact(60)
Despite their importance, relatively little is known about valve development.
Despite their importance, these reforms did not transform education.
Despite their importance, fundamental issues of neurosteroid actions remain unresolved.
Despite their importance, mechanisms maintaining lipid homeostasis remain poorly understood.
Despite their importance, most channel heads are unmapped.
Despite their importance, illegal shark fishing threatens roughly 25% of the world's sharks with extinction.
Despite their importance during the French Revolution, the Paris middle classes are little known.
Despite their importance, little is known about the indigenous microbiota of marine mammals.
Despite their importance to reef communities, little is known about them.
Despite their importance, few N-glycosites have been experimentally mapped in the Saccharomyces cerevisiae proteome.
Despite their importance, five popular marketing metrics are regularly misunderstood and misused.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com