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If the pool of minichromosomes containing RNAPII was simply related to the overall size of the pool of minichromosomes, we would expect to observe that the percentage containing RNAPII would remain constant despite the overall changes in the size of the pool following the different treatments.
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Despite the large electronic effects, the overall change in mass is marginal: −0.02 Da, accounting for the extra proton in the charged guanidinium group, or +0.98 Da, as encountered during mass spectrometric analyses of the neutral guanidine form.
But the overall change is misleading.
Table 1 shows that plasma leptin and adiponectin were significantly higher in the LRS group compared to the HRS, despite no overall change in body weight.
Despite no overall change in the number of crossovers in these hotspots, the distribution was significantly different between wild-type and nbs1-2 (chi-square test with Monte Carlo simulation, 2000 samplings, P < 0.01) such that two hotspots were expanded to neighboring intervals and one was lost (Table 4).
To address the possibility that, despite making no overall change in eye movements, subjects were changing their pattern of gaze over time (i.e. looking more or less at the relevant areas of the clip, such as the bodily contact during the violent acts), we drew regions of interest on each frame of each clip.
In previous work comparing microarray and NGS analysis of miRNA expression levels, we [ 23], and others [ 33], have reported variations in the statistical assessment of significantly dysregulated miRNAs despite the overall similarity in fold change values.
Despite the overall volumetric increase of both BW and GW in the entire basin, changes in their annual average values during the period of simulation reveal a distinctive spatial pattern.
One conundrum about recent changes to university finance is that every academic discipline feels hard done by, despite the overall protection in funding.
Despite the overall banality, the day's first panel was probably the best.
Despite the overall positive feedback from patients and favourable outcome from the brief intervention, there is still a small group of patients who are resistant to behaviour change.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com