Sentence examples for despite the major roles from inspiring English sources

Despite the major roles of SECs in metazoan gene expression and human disease, little is known about the architecture of these complexes.

Compared to their function in the development of autoimmunity, the roles of PI3K-Akt-mTORC1 signaling and HIF-1 of CD4+ T cells in the host defense are still largely unknown, despite the major roles of PI3K-Akt-mTORC1 pathway in APCs to regulate Th1- and Th17-type immune reactions (Fukao et al. 2002; Ohtani et al. 2008; Weichhart et al. 2008).

Despite the major role Hiroko had played in connection with the Dome's preservation, there was hardly any data available on her life.

Despite the major role of family peroxidases AA2 in lignin degradation, no AA2 protein was detected in the conditions using the hardwood substrate (birchwood).

Despite the major role of genetic factors in RA susceptibility, the concordance of this disease in monozygotic twins is only 15% [ 5].

The intermediate view, that despite the major role of HGT in the evolution of prokaryotes, TOL might be salvageable as a statistical "central trend," has been proposed as well (Wolf et al. 2002).

In addition, our study also found that sperm competition levels are also associated to the degree of elongation of the sperm head, a trait which has received little attention despite the major role it could play in sperm hydrodynamics.

Despite the major role attributed to the ascorbate-glutathione cycle in ROS alleviation, none of the proteins related to this process happened to belong to the Cd-responsive shoot proteome of M. truncatula, indicating that this pathway might not be operative upon Cd exposure in our experimental conditions.

Despite the major role of PLCζ in mammalian fertilization, thus far only purified recombinant mouse PLCζ has been successfully used to study in vitro biochemical properties and the regulatory mechanisms underlying PLCζ function (6, 8, 9, 11, 13).

In light of the major role observed for PIP2, despite its very low content in the membrane, we conclude that the binding free energy of the complex is minimized most efficiently by the macroion interacting primarily with PIP2 lipid molecules.

Despite VEGFR1 and VEGFR2 can bind VEGFA, VEGFR2 plays the major role in modulating these processes.