Toyota's fortunes haven't changed much from last year, despite the major recalls for unintended acceleration problems.
Despite the major dent, the progress fails to meet a W.H.O.
Despite the major human impact of Interpol red notices, there is no effective way to challenge cases of abuse.
Despite the major challenges facing our media institutions, there are bright spots that need to be developed further.
"Despite the major setback," he said, "these activities remain a core business of the Bayer Group that can contribute substantially to enhancing the company's value".
Even so, the Barbican and South Bank are not good enough for Simon Rattle, despite the major refurbishment of the Royal Festival Hall carried out just 10 years ago at considerable public cost.
Can it retain any credibility if the Crusaders are deemed to be worthy of another three-year stint, despite the major damage they did to Super League's image with last summer's visa scandal and the dash north to Wrexham?
Despite the major label behind it, Misty Circles only made it to No 100, though it would later find its way into millions of homes on the B-side of the band's biggest hit.
Despite the major coffee companies - Nestle, Kraft, Proctor & Gamble, Sara Lee, Starbucks - refusing to take part it is important to emphasise that Black Gold is not a film about Starbucks or about one company.
As things stand, despite the major shock of the Brexit vote, government departments are looking to make spending cuts and the government is still planning to cut its investment.
Despite the major rewards on offer in London in terms of prize-money and ranking points, the Davis Cup is Andy Murray's main target for the rest of this year.
