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Despite the initial optimism, the agreement faces considerable hurdles.
Despite the initial optimism, results from eight prospectively designed, randomized control studies powered to assess the value of adjuvant bone-targeted therapy in early breast cancer are conflicting.
Despite the initial optimism regarding adjuvant bisphosphonate therapy, the conflicting clinical results from large trials suggest that we should return to the bench to further investigate factors that may influence response to bisphosphonate treatment or identify appropriate characteristics that would indicate the sub-groups of patients most likely to benefit from bisphosphonate treatment.
Despite the initial optimism voiced by foreign investors when a right-leaning pro-market government came to power in 2017, such optimism has not been reflected in support for the peso.
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The officials at 10 Downing Street were amused by the initial optimism of the Obama Administration.
The initial optimism followed positive updates overnight from Apple and IBM.
For the families, the initial optimism that their children's foray into Isis would prove short lived have faded.
Elsewhere in Europe, the DAX in Frankfurt was flat despite initial optimism over a possible merger between NYSE Euronext and Deutsche Börse, owner of the Frankfurt Stock Exchange.
Despite great initial optimism, ribosomal RNA (and protein) sequences were of little or no help in understanding the evolution of photosynthesis and other fundamental biological processes.
Neither, despite initial optimism, was over by Christmas.
A less welcome record has been predicted in Scotland, however, with insect specialists fearing a rise in midge numbers despite initial optimism that cold weather in April and May may have hit their breeding pattern.
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CEO of Professional Science Editing for Scientists @ prosciediting.com