Unfortunately, despite the great development and sophistication of emergency systems, lots of patients die, and many of the survivors persist with different degrees of neurological handicaps.
Despite the great development in molecular studies, it is estimated that mutations in the SCN5A gene cause only about 18 30% of BS cases [ 17].
Despite a great development in mathematical modelling and advanced data processing of tracer kinetics, there is no standardized way to publish data from clinical studies.
Despite great development of organic synthesis, currently 75% of prescribed drugs worldwide are derived from plant sources [ 1], showing that plant species are still an important source of new drugs for diseases that continue to lack a cure, such as cancer.
Despite the great population increase and the high development expectations of Belo Horizonte, authorities have not invested enough in city planning, especially the urban mobility of 196,000 freight vehicles fleet that moves along the main streets.
Despite the great advancement recently achieved in the development of nanotechnology-based products, as demonstrated by the huge amount of nanomaterials that are present in the market nowadays, a thorough understanding of many biological issues related to these nanotools is still lacking.
Despite the great variety of computational tools available for assisting the development of such models, significant challenges are encountered in modeling living organisms and their mechanisms [ 34].
Despite the great reactivity of Ni- or Cu-based oxygen carriers, their development is restricted because of their relatively high cost.
