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'despite the difference' is a correct and usable phrase in written English.
It can be used to indicate that two things are not the same, but is not important enough to stop further progress. For example: "Despite the difference in opinion, the two sides managed to reach an agreement."
Exact(60)
It must be noted that despite the difference in probabilities, the two calculations are not all that different.
Despite the difference in our ages, we became friends.
Despite the difference in performance, Gaza 2008 was a replay of Lebanon 2006.
The similarity of phrasing and emphasis is striking, despite the difference in context.
Also, the ultimate phenol concentration remains constant despite the difference in initial phenol concentrations.
To recognize, despite the difference, or maybe because of it, some common humanity between us.
Despite the difference in style and setting, this turned out to be a familiar theme for me.
Despite the difference in the respective winning margins, however, it was Tony Mowbray's side who delivered the more impressive performance.
Despite the difference in personal style, it is hard to tell how that will play out in the magazine.
But despite the difference in styles, Trump and Obama had the same aim with their statements, Lakoff said.
Despite the difference in their political proclivities, she decided to give Barry the benefit of the doubt.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com