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Similarly, bone defects of greater than 25%-30%-30%thumeralral head tend to warrant surgical treatment; although often in this setting, reconstruction of the glenoid restores smooth articulation with the humeral head, despite the defect, and no further treatment is required.
"The hole in his trunk was a good 5 centimeters -- it had started to heal, and he was using it well despite the defect".
Despite the defect in dendrite morphology [21], therefore, the essential biophysical properties of Purkinje neurons (as measured at the cell soma) are unaffected by P-Rex-deficiency.
Despite the defect in chromosome condensation due to the obviously impaired function of the protein, the Mcph1gt/gt-mice do not show any striking physical phenotype.
Surprisingly however, severe viral infections have never been reported in these patients, despite the defect in HLA class I-mediated presentation of viral antigens to cytotoxic T cells.
Despite the defect in integrin-β1-mediated FAK activation, FAK was still localized to focal adhesions.
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Elgar was deeply depressed, but the critics recognised the mastery of the piece despite the defects in performance.
Despite the defects in BCR signalling, XBP-1KO/MD4 mice have normal numbers of B cells and B-cell subsets.
In addition, despite the defects already described and in particular the decreased branch number, examples of all three modes of branching were visible in Celsr1 Crsh and Vangl2 Lp homozygous lungs (Fig. 4C, D and data not shown) providing further evidence that Celsr1 and Vangl2 are part of a general mechanism governing bud/branch formation.
Thus, there were no apparent abnormalities in lung structure or clearance function in SNAP23 Het mice despite the defects in mucin secretion, suggesting a threshold above which partial mucin secretory function is sufficient to support normal lung structure and clearance function.
Despite of the defect in secretory control, the derivatives (EZ44, EZ52 and EZ64) retained the capability to assemble translocons and translocate the effector, resulting in wild-type levels of cytotoxicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com