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The phrase "despite the appearance" is correct and can be used in written English.
It is typically used to introduce a surprising or unexpected fact or piece of information that contradicts what might be expected based on the appearance of something. Example: Despite the appearance of being well-organized and efficient, the company was actually struggling financially and on the brink of bankruptcy.
Exact(60)
Despite the appearance of a normal cytoarchitecture, the overall size of the P28 cerebellum appeared smaller in whole-mount sagittal cross-sections of Math1-Bmi1 micomparedred with wild-type littermates (Fig. 2A,B).
And despite the appearance of look-Ma-no-hands, they are being conducted.
But despite the appearance of a head-to-head clash, it was nothing of the sort.
Despite the appearance of simplicity, there are a multitude of things going on here.
And despite the appearance of political calm, these are brittle regimes.
But reform was delayed, and, despite the appearance of illegality, the king collected these levies to prevent bankruptcy.
Despite the appearance of conscientious objectors as hospital orderlies there is precious little talk of heroism or even moral justification.
But despite the appearance of structure, reinforced by the pinstripes, the clothes move dynamically over the body.
The Shrimp takes a liking to the doctor's lifestyle and decides to stick around for a while, despite the appearance of the doctor's wife (Jo de Winter).
Despite the appearance of coral fossils during this time, reef ecosystems continued to be dominated by algae and sponges, and in some cases by bryozoans.
Despite the appearance of ecological processes progressing at a leisurely pace, scientists often find themselves in a race to understand swiftly changing paradigms.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com