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Survival and quality of life for patients on hemodialysis therapy remain poor despite substantial research efforts.
Despite substantial research efforts applied to the prediction of brake squeal noise since the early 20th century, the mechanisms behind its generation are still not fully understood.
Despite substantial research efforts made since the early 1990s, including gene mapping studies (for review see [ 8]), OC D) pathogenesis remains unclear [ 9], probably due to the confusion regarding disease definition and the lack of precise data about mechanisms of primary lesion formation [ 4].
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Despite the substantial research efforts on network coding, its real-world implementation is mainly over wireless networks or peer-to-peer networks.
Despite that substantial research efforts have been made on mechanical characterization of various one-dimensional (1-D) nanomaterials under quasi-static loading, very few works have been done so far on the challenging fatigue testing of individual 1-D nanostructures, in particular for their high-cycle fatigue behavior.
In addition, in spite of substantial research efforts, these systems have been poorly documented.
Substantial research efforts have been aimed at the discovery and qualification of new biomarkers of kidney and liver toxicity.
Despite a substantial research effort over the past 50 years, a vaccine licensed for clinical use has not yet been delivered and several challenges remain to be addressed.
Despite a relatively small number of experimental structures, substantial research effort during the last decade revealed many distinctive features of TM helix‐helix interactions.
The last decade has demonstrated a substantial research effort concerning dual data cache (DDC) systems.
The field of natural computing has been the focus of a substantial research effort in recent decades.
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